Detalhe da pesquisa
1.
Structural basis for substrate selection by the SARS-CoV-2 replicase.
Nature
; 614(7949): 781-787, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36725929
2.
Clinical targeting of HIV capsid protein with a long-acting small molecule.
Nature
; 584(7822): 614-618, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32612233
3.
An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp15.
J Biol Chem
; 297(4): 101218, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34562452
4.
Protein Footprinting and X-ray Crystallography Reveal the Interaction of PD-L1 and a Macrocyclic Peptide.
Biochemistry
; 59(4): 541-551, 2020 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31841311
5.
Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9.
J Biol Chem
; 292(16): 6810-6820, 2017 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28235803
6.
Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
Bioorg Med Chem Lett
; 27(8): 1840-1847, 2017 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28274633
7.
Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase.
Antimicrob Agents Chemother
; 57(2): 804-10, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23183437
8.
Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus.
PLoS One
; 17(12): e0271145, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36477212
9.
Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A.
J Med Chem
; 60(3): 1000-1017, 2017 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28075591
10.
Viral replication. Structural basis for RNA replication by the hepatitis C virus polymerase.
Science
; 347(6223): 771-5, 2015 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25678663
11.
Hepatitis C virus therapies: current treatments, targets and future perspectives.
Antivir Chem Chemother
; 14(1): 1-21, 2003 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12790512
12.
An adaptive mutation in NS2 is essential for efficient production of infectious 1b/2a chimeric hepatitis C virus in cell culture.
Virology
; 422(2): 224-34, 2012 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22099378
13.
Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCV.
J Mol Biol
; 405(5): 1139-53, 2011 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21145896
14.
Structure of human uridine-cytidine kinase 2 determined by SIRAS using a rotating-anode X-ray generator and a single samarium derivative.
Acta Crystallogr D Biol Crystallogr
; 61(Pt 3): 278-84, 2005 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15735337
15.
Crystal structure of complete rhinovirus RNA polymerase suggests front loading of protein primer.
J Virol
; 79(1): 277-88, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15596823